Caspase Functions in Cell Death and Disease: Figure 1.
نویسندگان
چکیده
منابع مشابه
Caspase functions in cell death and disease.
Caspases are a family of endoproteases that provide critical links in cell regulatory networks controlling inflammation and cell death. The activation of these enzymes is tightly controlled by their production as inactive zymogens that gain catalytic activity following signaling events promoting their aggregation into dimers or macromolecular complexes. Activation of apoptotic caspases results ...
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Caspase-mediated apoptosis is the death program of choice in many developmental and physiologic settings (Kerr et al., 1972; Strasser et al., 2000; Kaufmann and Hengartner, 2001). It would, however, be very dangerous for the organism to depend on a single protease family for clearance of unwanted and potentially dangerous cells. Indeed, the exclusive role of caspases in the execution of program...
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Triglyceride (TG) induces macrophage cell death which contributes to the development of atherosclerosis. We confirmed that exogenous TG accumulates in human THP-1 macrophages and causes cell death. TG treated THP-1 macrophages exhibited no change in tumor necrosis factor (TNF)-α, interleukin (IL)-18, macrophage inflammatory protein (MIP)-1α, and IL-1R1 receptor mRNA expression. However, there w...
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ژورنال
عنوان ژورنال: Cold Spring Harbor Perspectives in Biology
سال: 2015
ISSN: 1943-0264
DOI: 10.1101/cshperspect.a026716